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・ Streptomyces chryseus
・ Streptomyces chumphonensis
・ Streptomyces cinereorectus
・ Streptomyces cinereoruber
・ Streptomyces cinereospinus
・ Streptomyces cinereus
・ Streptococcus thermophilus
・ Streptococcus tigurinus
・ Streptococcus uberis
・ Streptococcus vestibularis
・ Streptococcus zooepidemicus
・ Streptoduocin
・ Streptoglossa
・ Streptogramin
・ Streptogramin A
Streptogramin B
・ Streptogrisin A
・ Streptogrisin B
・ Streptogyna
・ Streptokinase
・ Streptolabis
・ Streptolidine
・ Streptolirion
・ Streptolophus
・ Streptolydigin
・ Streptolysin
・ Streptomonospora alba
・ Streptomonospora amylolytica
・ Streptomonospora flavalba
・ Streptomonospora salina


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Streptogramin B : ウィキペディア英語版
Streptogramin B
Streptogramin B is a subgroup of the streptogramin antibiotics family. These natural products are cyclic hexa- or hepta depsipeptides produced by various members of the genus of bacteria ''Streptomyces''. Many of the members of the streptogramins reported in the literature have the same structure and different names; for example, pristinamycin IA = vernamycin Bα = mikamycin B = osteogrycin B.
==Biosynthesis==

The biosynthesis of streptogramin B is carried out by large multifunctional enzymes called non-ribosomal peptide synthetases (NRPS). In the NRPS system, each amino acid is activated as an aminoacyladenylate and is linked to the enzyme as a thioester with a phosphopantetheinyl group. An elongation reaction then occurs by transferring the activated carboxyl to the amino group in the next amino acid, thus executing the N-to-C stepwise condensation.
NRPSs contain several modules on a single polypeptide. Each of these modules can catalyze activation, condensation and a modification reaction specific to one kind of amino acid. A typical elongation module consists of an adenylation domain (A), a peptidyl carrier protein domain (PCP) and a condensation domain (C). Some other domains may be present that are responsible for modifications to the residues, such as epimerization domain (E) and N-methyltransferase domain (MT). The domain responsible for the termination is the thioesterase domain (TE) located in the final module.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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